Trinnpris angis for ikke-patenterte legemidler, hvor det foreligger generisk konkurranse mellom legemidler som Direktoratet for medisinske produkter har vurdert som likeverdige.
Various other medicines may alter the blood amounts of modafinil, and vice versa. Tell your Health care company about all medicines that you choose to just take or have not too long ago taken.
For those who skip a dose, consider it the moment you don't forget. If it is nearly time for your personal subsequent dose or near to bedtime, skip the missed dose and only just take the subsequent dose. Usually do not consider double or excess doses. Using a dose as well near bedtime may perhaps enable it to be harder so that you can slumber.
apalutamide will minimize the level or impact of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Keep away from or Use Alternate Drug. Coadministration of apalutamide, a strong CYP2C19 inducer, with medicines that are CYP2C19 substrates can result in decrease exposure to those medications.
cenobamate will enhance the stage or effect of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep track of Carefully. Think about a dose reduction of CYP2C19 substrates, as clinically ideal, when used concomitantly with cenobamate.
Watch Closely (one)levoketoconazole will enhance the stage or outcome of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Steer clear of or substitute An additional drug for these remedies when achievable. Examine for loss of therapeutic influence if medication should be coadministered. Change dose according to prescribing information and facts if required.
Ishizuka et al (2003) calculated Mind histamine launch using microdialysis in vivo in rats offered modafinil intraperitoneally, intraventricullarlry, or right in the tuberomamillary nucleus (TMN) and located that modafinil experienced no effect on HA when administered immediately in the TMN neurons, and experienced the swiftest impact on histamine when specified ip, indicating that modafinil did not directly target the TMN.
Keep track of Closely (1)modafinil will increase the degree or result of citalopram by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Check. Citalopram 20 mg/day is the maximum recommended dose for patients taking CYP2C19 inhibitors due to hazard of QT prolongation.
tecovirimat will increase the amount or result of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep track of. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Monitor for adverse results if coadministered with delicate substrates of these enzymes.
Even so, the waking system of modafinil is here yet for being thoroughly revealed. Current reports described that modafinil may be topic to abuse and habit. Also extended sleeplessness induces worry responses and impairs immune function.
Even though fewer common, essentially the most critical Unintended effects of modafinil are explained underneath, coupled with how to proceed whenever they transpire.
The above data is delivered for general informational and educational reasons only. Specific options may range and formulary information adjustments. Call the applicable approach service provider for quite possibly the most recent facts.
ceritinib will improve the stage or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.